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. 2012 Mar 23;205(10):1593–1600. doi: 10.1093/infdis/jis239

Figure 1.

Figure 1.

Transcript abundance of each group of var genes in parasites causing severe or mild malaria. Transcript abundance is relative to 2 conserved ring-stage transcripts. Data are for isolates from 56 patients with mild malaria and 60 with severe malaria. Boxes indicate medians and interquartile ranges (IQRs), and whiskers indicate 1.5 times the IQRs. *Nominal statistical significance (false discovery rate [FDR] q < 0.1) and ***statistical significance (FDR q < 0.01), by the nonparametric Mann–Whitney U test. A, Chromosomal arrangement of var gene groups. B, Transcript abundance of upsA and E var genes. Three degenerate primer pairs recognize conserved regions within upsA genes; one recognizes the conserved upsA subgroup, termed var3; one recognizes the unique upsE upstream sequence. C, Transcript abundance of upsB var genes (2 degenerate primer pairs recognizing upsB upstream sequences). D, Transcript abundance of upsC var genes (2 degenerate primer pairs recognizing upsC upstream sequences).