Methodological quality |
A. Least bias; results are valid |
B. Susceptible to some bias, but not sufficient to invalidate the results |
C. Significant bias that may invalidate the results |
Applicability |
I. Sample is representative of the target population. It should be sufficiently large to cover both sexes, a wide age range, and other important features of the target population (e.g. diet). |
II. Sample is representative of a relevant sub-group of the target population, but not the entire population. |
III. Sample is representative of a narrow subgroup of subjects only, and is of limited applicability to other subgroups. |