TABLE 3.
Serum and tissue β-carotene and lycopene concentrations and percent all-trans lycopene isomer in CMO I WT and CMO I KO mice fed β-carotene or lycopene diets for 60 d1
|
β-Carotene2 |
Total lycopene3 |
All-trans lycopene3 |
||||
|---|---|---|---|---|---|---|
| Group | βC-WT | βC-KO | Lyc-WT | Lyc-KO | Lyc-WT | Lyc-KO |
| μmol/L | % | |||||
| Serum | 0.76 ± 0.20 (6) | 10.31 ± 0.99 (6)** | 0.59 ± 0.11 (4) | 0.61 ± 0.078 (6) | 19.0 ± 2.1 (4) | 8.5 ± 1.3 (6)* |
| nmol/g | ||||||
| Liver | 18.0 ± 2.2 (6) | 246 ± 61 (6)* | 469 ± 107 (6) | 100 ± 18 (6)** | 51.3 ± 2.8 (5) | 27.6 ± 1.1 (5)** |
| Spleen | 25.0 ± 6.6 (7) | 89.4 ± 15.9 (6)** | 270 ± 41 (7) | 29.8 ± 6.5 (6)** | 58.9 ± 1.0 (5) | 45.9 ± 1.6 (5)** |
| Adrenals4 | 20.2 ± 1.5 (7) | 266.7 ± 8.7 (7)** | 48.8 ± 15.3 (7) | 37.9 ± 14.4 (4) | 32.0 ± 2.3 (7) | 17.9 ± 1.6 (4)** |
| Kidney | 1.53 ± 0.16 (6) | 22.5 ± 1.5 (6)** | 2.60 ± 0.21 (12) | 3.75 ± 0.51 (12) | 47.5 ± 2.8 (5) | 30.2 ± 2.1 (5)** |
| Lungs | 2.05 ± 0.17 (8) | 22.7 ± 2.4 (8)** | 1.94 ± 0.38 (7) | 1.38 ± 0.21 (6) | 41.1 ± 2.7 (7) | 18.7 ± 1.2 (6)** |
| Brain | 0.072 ± 0.019 (6) | 1.44 ± 0.18 (5)* | 0.019 ± 0.005 (6) | 0.048 ± 0.006 (5)* | ND5 | ND |
| Thymus4 | 3.74 ± 0.39 (4) | 37.4 ± 3.6 (4)** | 4.71 ± 1.03 (5) | 2.24 ± 0.47 (4)* | ND | ND |
| Adipose | 2.08 ± 0.99 (6) | 45.6 ± 10.8 (6)** | 3.06 ± 0.79 (5) | 4.90 ± 1.16 (5) | ND | ND |
| Uterus4 | 3.67 ± 0.58 (4) | 31.3 ± 4.6 (3)** | 4.43 ± 0.81 (4) | 3.29 ± 1.85 (2) | ND | ND |
| Prostate4 | 1.32 ± 0.07 (3) | 22.7 ± 5.6 (3)** | 0.81 ± 0.08 (3) | 3.24 ± 0.79 (3)* | 33.1 ± 1.3 (3) | 20.5 ± 1.3 (3)* |
| Testes | 3.56 ± 0.37 (6) | 37.4 ± 3.8 (6)** | 2.12 ± 0.14 (6) | 5.11 ± 0.80 (6)* | 25.6 ± 2.9 (6) | 20.3 ± 1.5 (6) |
| Seminal vesicles | 0.28 ± 0.10 (6) | 3.56 ± 0.50 (5)* | 0.04 ± 0.01 (6) | 0.15 ± 0.05 (5)* | 31.2 ± 3.3 (6) | 18.4 ± 0.9 (5)* |
1
Values are means ± SEM, (n). Asterisks indicate different from corresponding WT, *P < 0.05, **P < 0.001.
2
β-Carotene was not detected in mice fed placebo or lycopene beadlet-containing diets.
3
Lycopene was not detected in mice fed placebo or β-carotene beadlet-containing diets.
4
Pooled from 2–3 mice.
5
ND, Not determined.