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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: Integr Biol (Camb). 2010 Oct 5;3(1):39–47. doi: 10.1039/c0ib00053a

Fig. 2. Experimental system.

Fig. 2

A: Strategy for patterning osteogenic cell differentiation. Cultured cells with inducible BMP-2 expression are exposed to laminar flow with two streams (one with and one without Dox), generating a pattern of Dox concentration. The patterned Dox concentration profile leads to patterned BMP-2 expression, and thereby to patterned osteogenic differentiation. B: Flow channel (main channel: 20mm L × 6mm W × 0.1mm H).