TABLE 2.
Histopathologic Features
| Patient | Age | Type | Lobular Inflammation | Necrotic Hepatocytes | Giant Cells | Swelling | Pseudorosettes | Sinusoidal Fibrosis* | Portal-tract Inflammation | Ductular Reaction | Bile Plugs | Portal Fibrosis† |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 7 mo | B | Rare | Few | Common | Present | Prominent | 1 | Focal, mild | Absent | Canalicular | 1 |
| 2 | 18 mo | E | Rare | Absent/rare | Present | Rare | Present | 2 | Focal, mild | Absent | Canalicular | 2 |
| 3 | 12 mo | B | Rare | Absent/rare | Rare | Absent | Present | 1 | Focal, mild | Absent | Absent | 1 |
| 4 | 8 wk 20 mo |
B E |
Focal Focal |
Absent/rare Many |
Prominent Present |
Prominent Prominent |
Absent Present |
ND 4 |
Generalized, moderate to severe Generalized, moderate to severe |
Absent Generalized, mild |
Absent Canalicular and ductal/ductular |
ND 4 |
| 5 | 37 mo | E | Absent | Few | Rare | Prominent | Present | 4 | Focal, mild | Generalized, mild | Canalicular and ductal/ductular | 4 |
| 6 | 2 mo 6 mo 11 mo 16 mo |
B B B E |
Focal Absent Diffuse Focal |
Many Absent/rare Many Absent/rare |
Prominent Prominent Prominent Prominent |
Prominent Prominent Prominent Prominent |
Prominent Prominent Prominent Prominent |
0 4 4 4 |
Generalized, mild Focal, mild Generalized, mild Generalized, mild |
Absent Absent Absent Absent |
Canalicular Canalicular Canalicular Absent |
0 2 3 4 |
| 7 | 13 mo 17 mo 28 mo 9 y |
B B B B |
Focal Focal Rare Focal |
Absent/rare Absent/rare Few Absent/rare |
Present Rare Rare Rare |
Present Prominent Rare Present |
Present Prominent Absent Present |
3 3 3 4 |
Absent Generalized, moderate to severe Generalized, mild Generalized, mild |
Focal, mild Focal, mild Generalized, mild Absent |
Canalicular Canalicular Canalicular Canalicular |
2 1 1 1 |
| 8 | 7 mo 15 mo |
B B |
Rare Rare |
Absent/rare Few |
Present Present |
Prominent Rare |
Prominent Present |
3 4 |
Focal, mild Absent |
Focal, mild Absent |
Canalicular Canalicular |
2 3 |
| 9 | 7 y 7 y |
B E |
Rare Diffuse |
Absent/rare Absent/rare |
Rare Present |
Rare Rare |
Prominent Present |
2 4 |
Focal, mild Generalized, moderate to severe |
Absent Focal, mild |
Canalicular Canalicular |
4 4 |
| 10 | 21 mo | B | Diffuse | Absent/rare | Present | Rare | Present | 4 | Generalized, mild | Absent | Canalicular | 1 |
| 11 | 3 y 5 y |
B E |
Diffuse Diffuse |
Absent/rare Absent/rare |
Present Present |
Absent Absent |
Prominent Prominent |
4 4 |
Generalized, mild Generalized, mild |
Focal, mild Absent |
Canalicular Canalicular |
3 3 |
| 12 | 17 mo | E | Focal | Many | Present | Present | Prominent | 4 | Focal, mild | Focal, mild | Canalicular | 2 |
*
Sinusoidal fibrosis: 0, absent; 1, focal, confined to zone 3; 2, focal, extends beyond zone 3; 3, prominent, confined to zone 3; 4, prominent, extends beyond zone 3; ND, not determined (trichrome-stained section not available).
†
Portal fibrosis: Staged by Scheuer criteria.
B indicates biopsy specimen; E, explanted liver.