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Hsp90 plays an important role in maintaining the balance between soluble, active clients and insoluble, inactive proteins. The solubilities and/or activities of Hsp90 variants and clients monitored in this study are outlined. The high charge of Hsp90 concentrated in two charge-rich regions modulates this solubility-promoting function. Deletion of both charge-rich regions of Hsp90 impairs the solubility of Hsp90 and in turn reduces the solubility of complexes with clients.
