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Kinetics of early virus dissemination (A) and disease-free survival curves (B) for macaques infected i.v. (n = 9), i.r. (n = 11), or i.v.g. (n = 8) with a single high dose of R5 SHIVSF162P3N. Plasma RNA levels within the first 4 weeks of infection (A) and AIDS development over a 1-year infection period (B) are shown. A P value of <0.05 is considered statistically significant.
