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. 2012 Sep;86(17):9432–9442. doi: 10.1128/JVI.00852-12

Fig 4.

Fig 4

Comparison of virologic and immunologic measurements in RMs inoculated i.v.g. or i.r. with various doses R5 SHIVSF162P3N. (A) Viral load and peripheral CD4+ T cell counts in macaques receiving a single low intravaginal inoculum of 103 TCID50 R5 SHIVSF162P3N. A “+” indicates death due to euthanasia, and open symbols designate those macaques that resisted challenge. (B) Viral load in macaques inoculated i.r. with a single low (102 to 103 TCID50) or high (104 TCID50) dose of R5 SHIVSF162P3N. A “+” indicates euthanasia with clinical symptoms of AIDS. Dotted line in panels A and B mark a set-point of 5 log10 RNA copies/ml of plasma. (C) Peak and cumulative viral load (area under the curve over a 1-year infection period) comparison of R5 SHIVSF162P3N i.v.g.- and i.r.-infected macaques. The line represents the median viral RNA copies for each group. An asterisk (*) indicates statistical significance (P < 0.05).