Fig 5.
(A) Virologic and immunologic measurements in RMs (n = 7) receiving two doses of 104 TCID50 R5 SHIVSF162P3N administered i.v.g. twice within the day. A “+” indicates euthanasia with clinical symptoms of AIDS, open symbols designate the macaques that resisted challenge, and dotted line marks a set-point of 5 log10 RNA copies/ml of plasma. (B) Peak viremia and cumulative viral load comparison of macaques infected i.v.g. with various doses. The line represents the median viral RNA copies for each group. An asterisk (*) indicates statistical significance (P < 0.05). (C) Virus dissemination in macaques infected i.v.g. with different doses of SHIVSF162P3N. Plasma RNA levels within the first 8 weeks of infection are shown.