TABLE 3.
Effect of host factors on R5 SHIVSF162P3N i.v.g. challenge
| Dose (TCID50) | Animal | Age (yrs) | Wt (kg) | No. of births | Infection outcomea | MHC (Mamu) allele |
TRIM5 allele | ||
|---|---|---|---|---|---|---|---|---|---|
| A*01 | B*08 | B*17 | |||||||
| 1,000 | DG17 | 8.98 | 5.83 | 3 | RP | – | – | – | TFP/TFP |
| GC70 | 5.76 | 5.6 | 0 | RP | – | + | – | TFP/Q | |
| CG45 | 11.47 | 9.4 | 4 | CP | – | – | + | TFP/Q | |
| CG63 | 11.55 | 8.0 | 4 | CP | – | – | – | TFP/TFP | |
| CK46 | 12.03 | 6.5 | 5 | Resistant | – | – | – | TFP/TFP | |
| GH76 | 6.05 | 6.75 | 0 | Resistant | – | – | – | TFP/Q | |
| 10,000 | EL48 | 7.3 | 6.05 | 1 | RP | – | – | – | TFP/Q |
| EI77 | 7.57 | 4.3 | 0 | RP | – | – | – | TFP/Q | |
| FR25 | 6.84 | 8.85 | 0 | CP | – | – | – | TFP/TFP | |
| FV44 | 6.53 | 8.3 | 0 | CP | – | + | – | TFP/Q | |
| GH62 | 5.66 | 6.5 | 0 | CP | – | – | – | Q/Q | |
| CC50 | 7.16 | 9.3 | 1 | CP | – | + | – | TFP/Q | |
| GR56 | 5.48 | 7.45 | 0 | CP | – | – | – | TFP/TFP | |
| CA33 | 7.25 | 7.8 | 1 | CP | – | – | – | TFP/TFP | |
| BK49 | 8.56 | 7.05 | 1 | Resistant | – | – | – | TFP/TFP | |
| CR18 | 6.59 | 6.8 | 0 | Resistant | – | – | – | TFP/TFP | |
| EA19 | 8.65 | 8.55 | 0 | Resistant | – | – | – | TFP/Q | |
| EK83 | 7.69 | 9.0 | 0 | Resistant | – | – | – | TFP/Q | |
| 10,000 × 2 | CF18 | 9.98 | 5.2 | 5 | CP | – | – | – | Q/Q |
| FH84 | 7.44 | 4.7 | 0 | CP | – | – | – | TFP/Q | |
| AH94 | 12.27 | 11.1 | 6 | Transient | – | – | – | TFP/Q | |
| DE37 | 9.73 | 5.6 | 3 | Transient | – | – | – | TFP/TFP | |
| FE47 | 6.7 | 10.14 | 1 | Transient | + | – | – | TFP/Cyp | |
| EM01 | 7.68 | 8.9 | 1 | Resistant | – | – | – | TFP/Q | |
| V083 | 14.84 | 14.6 | 8 | Resistant | – | – | – | TFP/TFP | |
a
RP, rapid progressor; CP, chronic progressor.