TABLE 1.
Correlation of serum HBV DNA, HDV RNA, and HBsAg levels and age with disease courses
Patient group, no. (sex), and age (yr) | HBV type | HDV type | Outcome | ALT (U/liter) | ASTa (U/liter) | HBV DNA (copies/ml) | HBsAg (IU/ml) | HDV RNA (copies/ml) |
---|---|---|---|---|---|---|---|---|
Disease remission | ||||||||
I (M) | ||||||||
50b | B | 1 | CHD | 360 | 176 | 19,200 | 184.2 | 36,320 |
51c | CHD | 128 | 48 | 38,700 | 118.6 | 552,253 | ||
53d | CHD | 295 | 129 | 346,000 | 631.3 | 10,882,490 | ||
56 | Remission | 41 | 28 | <300 | 0.1 | <400 | ||
66 | Remission | 20 | 16 | <300 | 0 | <400 | ||
II (M) | ||||||||
28c | B | 2 | CHD | 107 | 80 | <300 | 2670 | 82,200,000 |
40d | CHD | 129 | 76 | <300 | 1831.6 | 19,800 | ||
42 | Remission | 14 | 21 | <300 | 0.1 | <400 | ||
43 | Remission | 33 | 21 | <300 | 0 | <400 | ||
III (M) | ||||||||
33c | NDe | 4 | AHDf | 1,235 | 645 | <300 | 6,458 | 32,200,000 |
44d | CHD | 61 | 55 | <300 | 3,643 | 2,05,200 | ||
50 | Remission | 16 | 23 | <300 | 0.1 | <400 | ||
61 | Remission | 21 | 23 | <300 | 0.1 | <400 | ||
IV (M) | ||||||||
27c | B | 4 | AHD | 926 | 502 | 987 | 784 | 2,755,440 |
29d | CHD | 117 | 83 | <300 | 138.4 | 185,884 | ||
44 | Remission | 14 | 19 | <300 | 0.2 | <400 | ||
45 | Remission | 22 | 23 | <300 | 0.2 | <400 | ||
Disease progressiong | ||||||||
V (F) | ||||||||
24c | C | 4 | CHD | 179 | 153 | 14,900 | 11,456 | 303,200,000 |
29d | CHD | 79 | 62 | 189,800 | 7,825 | 89,600,000 | ||
33 | CHD | 56 | 48 | 66,348 | 9,875.2 | 29,300,000 | ||
VI (M) | ||||||||
48c | B | 1 | Cirrhosis | 32 | 26 | <300 | 945.4 | 4,076,000 |
53d | Cirrhosis | 44 | 36 | <300 | 829.2 | 1,064,000 | ||
56 | Cirrhosis | 17 | 16 | <300 | 542.1 | 3,236 | ||
63 | Cirrhosis | 25 | 19 | 1,164 | 77.8 | <400 | ||
67 | Cirrhosis | 22 | 20 | <300 | 73.8 | <400 | ||
VII (F) | ||||||||
52c | B | 4 | HCC | 41 | 23 | <300 | 309.6 | 840,000 |
56d | HCC | 45 | 41 | 2,060 | 841.5 | 1,968,560 | ||
58 | HCC | 55 | 50 | 3,270 | 1,372 | 1,138,134 |
AST, aspartate transaminase.
First time point.
Early time point.
Late time point.
ND, nondetectable.
AHD, acute hepatitis D.
With persistently elevated ALT or adverse outcomes (cirrhosis or HCC).