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Weight loss of mice infected with parental 1918 influenza and AI viruses and eight chimeric 7:1 1918 influenza viruses bearing each of the gene segments of the AI H1N1 virus, respectively. Seven- to eight-week-old female BALB/c mice were intranasally inoculated with 103 PFU of the indicated viruses (see Table 2 and color-coded key) and weighed daily (5 mice per virus per group). P.I., postinoculation.
