Table 3.
Specimen and day | Virus titer (log10 PFU/ml) in the indicated animals infected with: |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Norway3568 virus |
Norway3487 virus |
|||||||||
367c | 368e | 369 | 370c | 371c,e | 372e | 373c,e | 374d | 375c | 376c | |
Nasal wash | ||||||||||
1 | 3.6 | 5.1 | 3.9 | —b | 3.1 | — | 2.6 | — | — | — |
3 | 1.8 | — | 1.9 | 1.8 | — | 1.9 | 1.6 | — | — | — |
5 | 1.3 | 1. 8 | 2.5 | — | — | 1.6 | — | NAf | — | — |
7 | — | — | — | — | — | — | — | NA | — | — |
10 | NA | — | — | NA | NA | — | NA | NA | NA | NA |
14 | NA | — | — | NA | NA | — | NA | NA | NA | NA |
Tracheal brush | ||||||||||
1 | 1. 8 | 4.2 | 5.3 | — | 3.0 | 2. 8 | 4.8 | 1.6 | 2.2 | 2.2 |
3 | 1.3 | 3.6 | 1.3 | 4.0 | — | — | 3.4 | — | — | — |
5 | 3.9 | 5.0 | — | 2.6 | — | — | 3.6 | NA | 2.2 | 2.7 |
7 | — | 2.2 | 3.9 | — | — | 3.1 | 3.6 | NA | — | — |
10 | NA | — | — | NA | NA | — | NA | NA | NA | NA |
14 | NA | — | — | NA | NA | — | NA | NA | NA | NA |
BALg fluid | ||||||||||
1 | 4.4 | 4.1 | 6.5 | 4.1 | 4.5 | 4.6 | 6.7 | 6.3 | 6.6 | 5.3 |
3 | 3.2 | 3.6 | 2.5 | 3.9 | 2.7 | 4.7 | 4.1 | 4.7 | 4.3 | 4.6 |
5 | 1.6 | 2.6 | 1.3 | 3.6 | 2.2 | 5.8 | 4.3 | NA | 4.5 | 4.1 |
7 | — | — | — | — | — | — | — | NA | — | — |
10 | NA | — | — | NA | NA | — | NA | NA | NA | NA |
14 | NA | — | — | NA | NA | — | NA | NA | NA | NA |
Cynomolgus macaques were infected with 6.7 × 107 PFU through multiple routes. Nasal wash and tracheal brush samples were collected every other day for virus titration.
—, virus not detected (detection limit, 1.3 log10 PFU/ml.
These animals were euthanized on day 7 postinfection for virologic and pathological analyses.
This animal died during the bronchoalveolar lavage procedure on day 3 postinfection.
These animals had Plasmodium spp. in their erythrocytes; however, their erythrocyte counts were normal.
NA, not applicable.
BAL, bronchoalveolar lavage.