Fig 1.
Deficiency of Nrf1 leads to impairment of hepatocellular functions. (A) Nrf1 mRNA expression in the livers from Nrf1dN/+ (control) and Nrf1dN/−:Alb-Cre (CKO) mice at 3, 4, and 6 weeks of age. Nrf1 mRNA expression was examined by qPCR. (B) Serum ALT activity in control and Nrf1-CKO mice. The data represent the mean ± SD (n = 3). P values are from Student's unpaired t test: *, P < 0.05; **, P < 0.01. (C to F) Liver sections from control and Nrf1-CKO mice at 3 weeks (C and D) and 5 weeks (E and F) of age were stained with oil red O. Bars, 100 μm.