Fig 1.

Identification of posttranslational modifications in MeCP2e1. (A) Amino acid sequence of mouse MeCP2e1, showing residues identified by MS/MS in red. The green box indicates the methyl-DNA binding domain (MBD), and the blue box indicates the transcriptional repression domain (TRD). (B) Visual representation of the putative modification sites identified in this study in relationship to the defined domains of MeCP2 using human MeCP2e2 amino acid numbers. NTD, N-terminal domain; ID, interdomain; CTD, C-terminal domain.