Course of disease in ferrets infected with nonrecombinant or recombinant CDV strains. (A) Body temperatures; (B) differential lymphocyte counts normalized for each animal to numbers of lymphocyte present at day 0; (C) survival curves. CDVR252, n = 6; rCDV5804P, n = 4; CDVSH, n = 3, rCDVSHdTom(6), n = 6; rCDVSHEGFP(6), n = 3. Data are shown as means per group. ***, the life expectancy of CDVR252-infected ferrets estimated by the Kaplan-Meier method was significantly greater (P < 0.05) than that of other ferret groups upon comparison using a log rank test.