Effects of heterozygosity on chronic-phase viral loads. (A) Mean viral loads (number of viral RNA copies per ml plasma) for all 27 MCM at 52 weeks postinfection. (B) Mean viral loads for a subgroup of 18 MHC-matched (six M1/M1, six M1/M3, and six M3/M3) MCM at 2, 12, 21, and 52 weeks postinfection with SIVmac239. The horizontal dashed line represents the threshold of viral control as defined for this cohort (1,000 copies/ml). There were no statistically significant differences between the different haplotypes.