Table 1.
Serum antibody neutralizing responses following seasonal TIV administration in ferrets
| Group | Neutralizing antibody titer (GMT)a |
|||
|---|---|---|---|---|
| A/Perth/16/2009 | A/Mexico/4482/2009 | B/Brisbane/60/2008 | 1918 | |
| Experiment 1 | ||||
| Prevaccination | <10 | <10 | <10 | <10 |
| Pre-1st booster vaccination | <10 | <10 | 20–80 (40) | <10 |
| Pre-2nd booster vaccination | 10–20 (11) | 10–40 (17) | 160–320 (211) | <10–10 (8) |
| Prechallenge | 20–80 (35) | 40–320 (121) | 160–640 (485) | 10–40 (23) |
| Experiment 2 | ||||
| Prevaccination | <10 | <10 | <10 | <10 |
| Pre-1st booster vaccination | <10 | <10–20 (5.9) | 20–80 (38) | <10 |
| Pre-2nd booster vaccination | ND | ND | ND | ND |
| Prechallenge | 20–160 (47) | 40–320 (136) | 40–320 (143) | 20–80 (28) |
a
Serum neutralizing antibody responses following primary and booster immunizations of 2010-2011 seasonal TIV are shown. ND, not done.