Fig 6.

Robust early CXCL10 and 2,5-OAS expression requires both IFN-α and -β. Using Q-PCR, the levels of mRNA for CXCL10 and 2,5-OAS were determined in the CNS of IFN-β^−/− (IFNb), IFNAR^−/− (IFNaR), and WT mice infected i.c. with LCMV 3 days earlier. The mRNA level in the brain of a sham-inoculated mouse was used as a set point (R = 1). The points represent individual mice, and group averages are indicated by horizontal lines. The asterisks indicate statistically significant differences between knockout and WT mice.