Fig 1.

SeV V⁻ propagation in lungs from gene-knockout mice. (A to C) Three-week-old gene-knockout mice and their parent strains, MDA5-KO C57BL/6 mice (A), RIG-I-KO ICR mice (B), and MDA5/RIG-I-KO ICR mice (C), were intranasally inoculated with 10⁶ CIU of SeV WT or SeV V⁻ per mouse and were sacrificed at certain time intervals. Their lungs were homogenized in 1 ml of MEM, followed by measurement of virus infectivity. Average infectivity is plotted in the graph, and a plus sign indicates death of a mouse.