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Growth phase modulation of Rgg binding specificity. In the exponential phase of growth, elevated glycolytic flux promotes a LacD.1 conformation (black circles) that forms a complex with Rgg (gray circles). Together, the proteins bind to Pemm49, PsfbX49, Psof, and PspeH to repress transcription. In the post-exponential phase of growth, decreased glycolytic flux causes a conformational change in LacD.1 that results in dissociation from Rgg and a change in the binding specificity of Rgg.
