Table 2.

Differentially expressed genes involved in cold stress response

Name	Locus taga	Description	Categoryb	P value			Fold change (log2) for CIRM-BIA strainc:
				Time	Strain	Time × strain	118	122	123	1	472	482	9
pspC	PFREUD_06710	Possible stress response transcriptional regulator protein	A	<0.01	<0.01	<0.01	3.8	2.0	2.9	3.5	2.6	4.3	4.0
pspC	PFREUD_06710	Possible stress response transcriptional regulator protein	A	<0.01	<0.01	<0.01	3.8	2.0	2.9	3.5	2.6	4.3	4.0
cspA	PFREUD_09800	Cold shock-like protein	A	<0.01	<0.01	0.01	−0.3	0.1	1.6	2.1	1.3	1.7	1.9
cspB	PFREUD_18210	Cold shock protein	A	<0.01	<0.01	0.01	0.8	0.6	1.1	2.3	0.8	1.8	0.9
	PFREUD_04260	DeaD/DeaH box helicase	DNA	<0.01	<0.01	0.21	0.3	0.7	0.7	1.2	0.9	1.0	0.8
	PFREUD_13460	Superfamily II RNA helicase, DeaD/DeaH box helicase	DNA	<0.01	<0.01	0.04	1.3	1.2	1.5	2.0	0.9	1.9	1.8
dnaK2	PFREUD_04630	Chaperone protein	PM	<0.01	<0.01	<0.01	−0.5	−1.8	−2.6	−2.5	−2.5	−0.5	0.5
grpE2	PFREUD_04640	Co-chaperone protein	PM	<0.01	0.04	<0.01	0.9	−0.9	−1.5	−2.4	−1.5	0.0	0.9
dnaJ2	PFREUD_04650	Chaperone protein DnaJ2	PM	<0.01	<0.01	<0.01	−0.3	−0.9	−1.4	−1.1	−0.7	0.4	0.6
groS1	PFREUD_06460	10-kDa chaperonin 1	PM	<0.01	0.02	0.01	−2.4	−4.1	−3.9	−5.5	−5.4	−5.9	−5.2
groL1	PFREUD_06470	60-kDa chaperonin 1	PM	<0.01	0.24	0.22	−3.0	−3.9	−3.8	−4.0	−4.6	−4.9	−4.7
groS2	PFREUD_07810	10-kDa chaperonin 2	PM	<0.01	<0.01	0.15	−0.8	−0.6	0.3	−0.7	−1.1	−0.2	−0.8
dnaJ3	PFREUD_08760	Chaperone protein DnaJ3	PM	<0.01	<0.01	<0.01	−0.4	0.0	−0.6	−1.6	−1.3	−0.3	−0.8
hsp20	PFREUD_09500	Heat shock protein 20 2	PM	<0.01	0.03	0.03	−1.3	−0.6	−0.3	−0.1	−0.1	−0.6	1.2
dnaJ1	PFREUD_17820	Chaperone protein DnaJ1	PM	<0.01	<0.01	<0.01	−2.8	0.0	−2.2	−2.7	−1.6	−2.3	−2.2
grpE1	PFREUD_17830	Co-chaperone protein	PM	<0.01	<0.01	<0.01	−3.0	0.1	−2.8	−3.2	−2.0	−3.0	−2.3
dnaK1	PFREUD_17840	Chaperone protein	PM	<0.01	<0.01	<0.01	−2.9	0.2	−3.2	−2.0	−2.5	−4.5	−1.7
clpB 2	PFREUD_17920	Chaperone protein	PM	<0.01	<0.01	<0.01	−2.9	−0.4	−3.5	−3.3	−2.1	−1.9	−4.1
groL2	PFREUD_18470	60-kDa chaperonin 2	PM	<0.01	0.37	0.65	−2.9	−3.7	−3.2	−3.4	−3.3	−4.1	−3.6
clpB 1	PFREUD_19250	Chaperone protein	PM	<0.01	<0.01	<0.01	1.9	0.7	−1.3	0.8	0.2	2.7	1.2

^aLocus tag for CIRM-BIA1^T.

^bA, adaptation to atypical conditions; DNA, DNA metabolism; PM, protein modification and folding.

^cValues of |fold change (log₂)| >1 are in boldface.