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. 2012 Aug 10;7(8):e42985. doi: 10.1371/journal.pone.0042985

Figure 2. Overexpression of TAp73α promoted cell apoptosis in response to cisplatin.

Figure 2

(A) TAp73α-overexpressed cells (SKOV3 C8, C24 and C28 and OVCA433 C1, C7 and C12) and the empty vector controls (V) of SKOV3 and OVCA433 were treated with 4 μg/ml cisplatin for 48 h. Apoptotic cells were assessed by TUNEL assay. More than 500 cells were counted for each group, the results presented were the relative of the apoptotic cells to total cells and at least three independent experiments were performed (**: p<0.01). (B) TAp73α-overexpressed cells and empty vector controls were treated with different doses (indicated) of cisplatin for 24 h, and the cleavage of PARP was detected by western blot analysis.