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. 2012 Aug 10;7(8):e42985. doi: 10.1371/journal.pone.0042985

Figure 5. TAp73α activated the JNK pathway through up-regulating GADD45α and the subsequent activation of MKK4.

Figure 5

(A) Increase of GADD45α mRNA expression in TAp73α-overexpressed cells (SKOV3 C8, C24 and C28 and OVCA433 C1, C7 and C12). (B) Increase of GADD45α protein expression and the MKK4 phosphorylation level in TAp73α-overexpressed cells (SKOV3 C8, C24 and C28 and OVCA433 C1, C7 and C12). (C) GADD45α was knocked down in TAp73α-overexpressed cells (SKOV3 C8 and OVCA433 C1) by siRNAs (Si1-GADD45α and Si2-GADD45α) treatment. The activation of MKK4, JNK and c-Jun were diminished, even under the cisplatin treatment.