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. 2012 Aug 10;7(8):e43074. doi: 10.1371/journal.pone.0043074

Figure 4. Photoreceptor morphology in control and safranal-treated P23H animals.

Figure 4

Vertical sections of retinas from P23H rats treated with vehicle (A–C) or safranal (D–F). Nuclei stained with TO-PRO (blue). (A, D) recoverin (red) stained retinas showing a more profuse degeneration in control animals (A) than that observed in safranal-treated rats (D). (B, E) Cone specific staining with γ-transducin (green) showing smaller cell size and shorter and swollen outer segments in control animals (B, arrowheads) as compared to safranal-treated rats (E) where all cone structures from outer segment (E, arrowhead) to pedicle (E, arrow) can be observed. (C, F) Double immunolabeling for recoverin and γ-transducin. All images were collected from the central area of the retina, close to the optic nerve. ONL: outer nuclear layer, OPL: outer plexiform layer. Scale bar: 10 μm.