Figure 1. Significant reduction of albuminuria by combination therapy: Final kidney parameters in diabetic eNOS knockout mice treated with riociguat (3 mg/kg/d), telmisartan (1 mg/kg/d), both (3 mg/kg/d and 1 mg/kg/d) or vehicle, and non-diabetic eNOS knockout mice treated with vehicle, respectively.

Urinary albumin-creatinine ratio (A), percentage reduction in urinary albumin excretion per day compared with diabetic controls (B) and cystatin C in Plasma (C). Values are given as means ± SEM. For comparisons, student's t test and Mann-Whitney u test, respectively, were used. ^* p<0.05 vs. diabetic vehicle; ^# p<0.05 vs. non-diabetic vehicle.