Figure 3. Significant reduction of MDA- positive renal tissue by combination therapy: Immunhistochemical detection of MDA in non-diabetic (A) and diabetic (B) untreated eNOS knockout mice.

Percent volume of MDA-positive area in renal cortex (F). Values are given as means ± SEM. For comparisons, student's t test was used. ^** p<0.01; ^***p<0.001 vs. diabetic vehicle and ^#p<0.05; ^##p<0.01 vs. non-diabetic vehicle. Abbreviations used: MDA, malondialdehyde.