Figure 7. Pak inhibitor, IPA3, reduced the contractility of isolated murine tracheal segments to ACh and 5-Ht in vitro.

Curves show responses of tracheal segments normalized to maximal response to ACh or 5-Ht prior to incubation with vehicle or IPA3. IPA3 treatment (open circles) significantly inhibited contractile responses to (A) ACh (n = 4) and (B) 5-Ht (n = 4) compared to responses of vehicle-treated tissues (black squares). Values are means ± SEM, significantly different, * p<0.05.