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(A) Structural representation of curcumin and the FLLL32 and FLLL62 diketone analogs. (B) Computational representation of FLLL32 and FLLL62 binding to the STAT3 SH2 domain. The SH2 surface was shown with electrostatic potential, with blue representing positive charged surface and red representing negative charges. Both compounds bind to the pTyr705 site identically with a slight difference occurring at the Leu706 site.
