Table 1. Summary of Temporal MHC studies including population demographic parameters important for generating temporal variation.

Organism	Locus	Fluctuating s	Fluctuating Nc	Parasite screen	Populations	Alleles	Ref
Great read warblers	MHC I	Yes	No	No	1	67	[50]
Soay Sheep	MHC II	Yes	Yes	No	4	8	[51]
Water vole (France)	MHC II	Yes	Yes	No	7	16	[52]
Brown trout	TAP2A	Yes	Yes	No	11	14	[53]
Water vole (Scotland)	MHC II	No	Yes	No	3	6	[38]
Brown hares	MHC II	No	No	Yes	1	10	[54]
Guppy	MHC II	Yes	Yes	Yes	9	66	[33]
Greater prairie-chickens	MHC II	No	Yes	No	1	24	[8]

‘Fluctuating s’ refers to studies which concluded that fluctuating selection may have increased temporal differentiation of immune genes relative to that of neutral markers. Studies that provided either direct evidence for changes in population size, or temporally unstable population structure, were considered to have a fluctuating census population size (‘Fluctuating N_c’). ‘Populations’ indicates the number of sampled populations and ‘Alleles’ indicates the total observed number of MHC alleles in the sampled metapopulation.