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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Hepatol Res. 2012 May 9;42(11):1119–1130. doi: 10.1111/j.1872-034X.2012.01026.x

Figure 2.

Figure 2

Gene expression profiling based on selected gene biomarkers of BDEsp ICC-derived cancer-associated myofibroblastic cells and cholangiocarcinoma cell strains. (A) Bar chart representation of 27 marker genes assessed by microarray analysis that showed significant differences in expression levels between BDEsp-TDFE4 and BDEsp-TDEH10 when cultured individually in a rat tail type I collagen gel matrix. (B) Robust Multiarray Analysis (RMA) expression summaries for the 27 analyzed biomarker genes shown in A, comparing orthotopic BDEsp ICC to organotypic BDEsp-TDFE4/BDEsp-TDEH10 culture. Postn, periostin; Col1a2, collagen type Ia2; Fn1, fibronectin 1; Igfbp7, insulin-like growth factor binding protein 7; Col1a1, collagen type Ia1; Mmp2, metalloproteinase-2; Igfbp5, insulin-like growth factor binding protein 5; Pdgfrb, platelet-derived growth factor receptor β; Tnc, tenascin-C; Vim, vimentin; Mmp11, metalloproteinase 11; Twist1, Twist homolog 1; Wisp1, WNT1 inducible signaling protein 1; Snail1, Snail homolog 1; Des, desmin; Acta2, smooth muscle actin; Hgf, hepatocyte growth factor; Sphk1, sphingosine kinase 1; Mmp7, metalloproteinase-7; Erbb2, c-erbB2 protooncogene receptor protein; Areg, amphiregulin; Lamc2, laminin gamma2; Tgfa, transforming growth factor α; Muc1, mucin 1; Krt7, cytokeratin 7; Cdh1, E-cadherin; Krt19, cytokeratin 19.