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. Author manuscript; available in PMC: 2013 Feb 9.
Published in final edited form as: Nature. 2012 Aug 9;488(7410):172–177. doi: 10.1038/nature11270

Figure 2. AGRP axon stimulation evokes feeding in PVH but not PBN.

Figure 2

a, Scheme for AGRP axon photostimulation in the PVH and ChR2:tdTomato distribution of bilaterally transduced AGRP axons in the PVH. Dashed line: optical fibre position. b, Food intake before and during photostimulation (1 h each) of AGRP axons in the PVH (n = 16 mice, 8 bilateral and 8 unilateral ChR2 transduction). Red line: somatic AGRP neuron-evoked food intake (ref. 4). c,d, Photostimulation of AGRP axons with a second optical fibre implanted over the PBN (the bilaterally transduced mice used in b). Paired t-test. Values are means ± s.e.m.