Table 2.

Approaches to further improve the potency and breadth of Ab responses elicited by immune complex vaccines.

Potency	Breadth
Immune complexes constructed with gp120 mutants lacking specific N- glycans to better expose targeted epitopes	Immune complexes formed with different gp120 antigens displaying distinct variants of targeted epitopes
Adjuvants targeting different TLRs or other pathogen recognition receptors	Immune complexes formed with different mAbs to enhance immunogenicity of different epitopes targeted on gp120
Use of gp120/mAb complexes as boosting immunogens following priming with DNA or other vectors	A cocktail of immune complexes to target multiple different epitopes and epitope variants