Table 1.

Molecular genetic features in 22 cases of histologically anaplastic PA

Case	Age	Sex	Location	NF1 clinical status	History of radiation	Necrosis	PTEN	BRAF	BRAF V600E	Chr7	P16	PDGFRA	EGFR	IDHR132H IHC
1	5	M	Cerebellum	Sporadic	No	No	NA	Dup	NA	Normal	Normal	No Amp	No Amp	Neg
2	70	M	Cerebellum	Sporadic	No	Yes	Het del	Normal	NA	Normal	HD	No Amp	No Amp	Neg
3	28	M	Cerebellum	Sporadic	Yes	Yes	WT	NA	NA	+7	NA	NA	No Amp	Neg
4	11	M	R frontal lobe	Sporadic	No	Yes	WT	Normal	WT	+7	Normal	No Amp	No Amp	Neg
5	36	F	Cerebellum	Sporadic	No	No	Het del	Dup	NA	+7	Normal	No Amp	No Amp	Neg
6	29	M	Cerebellum	NF1	No	No	Het del	Normal	NA	Normal	HD	No Amp	No Amp	Neg
7	20	M	Cerebellum	Sporadic	No	Yes	WT	Dup	NA	+7	Normal	No Amp	NA	Neg
8	27	M	Cerebellum	Sporadic	Yes	Yes	Het del	Dup	NA	+7	HD	No Amp	NA	Neg
9	75	M	L temporal lobe	Sporadic	No	No	WT	Normal	WT	+7	Normal	No Amp	No Amp	Neg
10	10	M	3rd ventricle	Sporadic	No	Yes	WT	Normal	NA	+7	Normal	No Amp	No Amp	Neg
11	39	F	Cerebellum	Sporadic	Yes	Yes	NA	Dup	NA	+7	Normal	No Amp	No Amp	Neg
12	46	M	L parietal lobe	NF1	No	Yes	WT	NA	NA	Normal	NA	NA	No Amp	Neg
13	46	F	R temporal lobe	NF1	No	No	WT	Normal	NA	+7	Normal	No Amp	NA	Neg
14	73	F	Tectum	Sporadic	No	Yes	WT	Normal	WT	+7	Normal	No Amp	No Amp	Neg
15	51	M	Spinal cord	Sporadic	No	No	Het del	Normal	NA	Normal	Normal	NA	No Amp	Neg
16	19	M	Cerebellum	NF1	No	No	WT	NA	NA	Normal	NA	NA	No Amp	NA
17	26	M	Cerebellum	NF1	No	Yes	WT	NA	NA	+7	NA	NA	No Amp	NA
18	16	M	Spinal cord	Sporadic	No	Yes	Het del	Normal	NA	+7	Normal	No Amp	No Amp	NA
19	49	F	Cerebellum	Sporadic	No	Yes	WT	Normal	NA	+7	NA	No Amp	No Amp	NA
20	21	F	Medulla	Sporadic	No	Yes	WT	Normal	WT	+7	Normal	No Amp	No Amp	NA
21	33	M	L parietal lobe	NF1	No	No	WT	NA	NA	+7	NA	NA	No Amp	NA
22	55	F	Cerebellum	Sporadic	NA	No	NA	Normal	NA	+7	NA	NA	NA	NA

NF1 neurofibromatosis type 1, Het del heterozygous deletions, HD homozygous deletions, WT wild type, Chr chromosome, No Amp no amplification, Neg negative, NA test failed or not done