Table 1.

The SCE frequency increases in cells depleted of LigI by lentiviral transduction

Cell line	SCEa	p b	n c
HeLa shCTL	0.169 ± 0.010		43 (2,839)
HeLa shLigI	0.326 ± 0.021	<0.0001	51 (3,370)
MCF7 shCTL	0.194 ± 0.009		40 (2,739)
MCF7 shLigI	0.281 ± 0.016	<0.0001	40 (2,728)
U2OS shCTL	0.141 ± 0.008		43 (3,184)
U2OS shLigI	0.216 ± 0.042	<0.0001	38 (2,776)

^aEquals the total number of sister chromatid exchanges divided by the total number of chromosomes counted; ± indicates the 95 % confidence interval

^bDetermined via the Mann–Whitney test

^cNumber of metaphase spreads from which the SCE frequency was determined; the values in parentheses indicate the total number of chromosomes analyzed in each lentiviral-transduced cell population