Table 1.
Cell line | SCEa | p b | n c |
---|---|---|---|
HeLa shCTL | 0.169 ± 0.010 | 43 (2,839) | |
HeLa shLigI | 0.326 ± 0.021 | <0.0001 | 51 (3,370) |
MCF7 shCTL | 0.194 ± 0.009 | 40 (2,739) | |
MCF7 shLigI | 0.281 ± 0.016 | <0.0001 | 40 (2,728) |
U2OS shCTL | 0.141 ± 0.008 | 43 (3,184) | |
U2OS shLigI | 0.216 ± 0.042 | <0.0001 | 38 (2,776) |
aEquals the total number of sister chromatid exchanges divided by the total number of chromosomes counted; ± indicates the 95 % confidence interval
bDetermined via the Mann–Whitney test
cNumber of metaphase spreads from which the SCE frequency was determined; the values in parentheses indicate the total number of chromosomes analyzed in each lentiviral-transduced cell population