Fig. 5. Effect of LBH589 and SAHA on GVHD.
B/c mice were lethally irradiated and transplanted with 5 × 106 TCD B6 BM cells with or without 1 × 106 T cells. Recipients were treated with PBS vehicle, SAHA (25mg/kg BW, daily treatment from day 0 to 7) or LBH589 (1.25mg/kg BW, every other day, from day 0 to 12) via i.p injection. (A) Mice survival was the combined data from 3 independent experiments. (n = 12-13) (B) Mice body weight (n = 4-5). Similar results were found in the repeated experiments. (C) GVHD pathological score of mice livers from the combination of 2 independent experiment (n = 8) **p<0.01; ***p<0.001.