Table 3. Simvastatin and Pravastatin Metabolite Concentrations in STRENGTH.

	Sex		SLCO1B1 genotype
Metabolite	Male	Female	*1/*1	*1/*5	*5/*5
Simvastatin Acid (20mg)	28 1.7 [0.8 – 2.9]	30 1.1 [0.4 – 2.1]	28 1.2 [0.5 – 2.1]	27 1.4 [0.7 – 2.9]	3 11.2 [7.9 – 17.2] 0.006*
Simvastatin Lactone (20mg)	28 0.5 [0.2 – 1.0]	30 0.4 [0.3 – 0.8]	28 0.5 [0.3 – 1.0]	27 0.4 [0.2 – 0.9]	3 0.4 [0.2 – 0.6]
Simvastatin Acid (80mg)	27 4.1 [1.5 – 8.2]	26 3.5 [1.6 – 5.3]	28 3.7 [1.3 – 5.3]	24 3.7 [1.6 – 9.2]	1 77.5 0.03*
Simvastatin Lactone (80mg)	27 1.3 [0.7 – 4.0]	26 1.2 [0.8 – 2.4]	28 1.1 [0.8 – 3.5]	24 1.4 [0.7 – 3.3]	1 3.7
Pravastatin acid (10mg)	28 0.2 [0.1 – 0.6]	25 0.2 [0.1 – 0.5]	25 0.2 [0.07 – 0.5]	27 0.2 [0.1 - 0.5]	1 0.2
Pravastatin lactone (10mg)	25 0.01 [0.01 – 0.02]	23 0.02 [0.01 - 0.03]	23 0.02 [0.01 – 0.03]	24 0.01 [0.01 – 0.02]	1 0.002
Pravastatin acid (40mg)	29 1.2 [0.6 – 3.6]	24 0.9 [0.4 – 1.9]	26 1.0 [0.4 – 2.1]	27 1.0 [0.5 – 3.6]	N/A
Pravastatin lactone (40mg)	29 0.06 [0.03 – 0.11]	25 0.05 [0.02 – 1.1]	26 0.07 [0.02-0.14]	27 0.05 [0.03 – 0.10]	N/A

Each cell contains the number tested, median (ng/ml), 25^th and 75^th percentiles (in brackets), and p-value where appropriate (based on linear regression on log transformed values);

N/A = no available sample;

^*p-value for comparison across genotypes;