Table 1.

UPS and ALP dysfunction in synucleinopathies

Table 1A. Dysfunction of the UPS in PD & DLB	Reference
Reduced proteasome activity in the SN of PD patients	[106,108,154]
Reduced expression of proteasomal subunits in the SN of PD patients or cortex of DLB patients	[20,29,95,106,107]
Reduced proteasome activity and expression of UPS related proteins in peripheral blood mononuclear cells	[15,157]
Altered proteasome function in toxin-based models of PD	[12,21,46,27,163,181]
Altered proteasome function in α-synuclein overexpressing rodent models	[24,44,39]

Table 1B. Dysfunction of the ALP in PD & DLB	Reference
Altered levels of autophagy-related proteins in PD or DLB patients	[1,29,32,35,57,71,86,151,152,179]
Altered autophagy function in peripheral blood cells	[123,171]
Altered autophagy function in toxin-based models of PD	[86,112,168]
Altered autophagy function in α-synuclein overexpressing rodent models	[29,32,179]