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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: Anal Chem. 2012 Jul 3;84(14):6031–6039. doi: 10.1021/ac300819a

Figure 2.

Figure 2

(a) A schematic illustration of the nanohole fabrication process using nanoimprint lithography. (b) A scanning electron micrograph (SEM) of a nanohole array. The hole diameter and periodicity are 200 nm and 500 nm, respectively. The inset to Figure 2(b) shows a photograph of the fabricated nanohole SPR chip. The nanohole array is patterned in a ~cm2 area in the middle of a gold-coated glass slide. (c) Schematic representation of a SLB on a gold nanohole array. The pentameric structures represent antibodies (IgM Abs), such as O1 and O4.