Table 2.
Serum 25(OH)D concentration for all groups at all study time points
| 25(OH)D (ng/ml) |
Change from baseline; ratio D3/D2 | P | 25(OH)D (ng/ml) |
Change from baseline; ratio D3/D2 | P | 25(OH)D (ng/ml) |
Change from baseline; ratio D3/D2 | P | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D3 (1600 IU daily) | D2 (1600 IU daily) | D3 (50,000 IU monthly) | D2 (50,000 IU monthly) | D3 (pooled daily and monthly dosing) | D2 (pooled daily and monthly dosing) | |||||||
| Base | 29.9 (2.5) | 32.0 (2.1) | 36.3 (2.1) | 31.1 (2.2) | 33.0 (1.7) | 31.5 (1.5) | ||||||
| 1 month | 34.4 (1.8) | 32.9 (2.0) | 1.13 (1.02–1.24) | 0.01 | 38.5 (2.2) | 32.5 (1.8) | 1.06 (0.96–1.16) | 0.27 | 36.4 (1.4) | 32.7 (1.3) | 1.09 (1.02–1.17) | 0.01 |
| 2 months | 35.9 (1.9) | 34.5 (1.7) | 1.11 (0.98–1.26) | 0.10 | 40.2 (2.4) | 32.8 (2.2) | 1.10 (0.97–1.25) | 0.13 | 38.0 (1.5) | 33.6 (1.4) | 1.11 (1.01–1.21) | 0.02 |
| 3 months | 37.5 (1.9) | 33.8 (1.8) | 1.19 (1.03–1.37) | 0.02 | 41.7 (2.4) | 32.8 (2.1) | 1.14 (0.99–1.32) | 0.07 | 39.6 (1.6) | 33.3 (1.4) | 1.17 (1.05–1.29) | 0.01 |
| 6 months | 40.3 (2.4) | 36.8 (2.0) | 1.17 (1.00–1.37) | 0.05 | 42.3 (2.5) | 34.1 (2.1) | 1.11 (0.94–1.30) | 0.20 | 41.3 (1.7) | 35.5 (1.5) | 1.14 (1.02–1.27) | 0.02 |
| 9 months | 39.5 (2.4) | 36.9 (2.1) | 1.14 (0.97–1.34) | 0.11 | 44.0 (2.8) | 35.1 (2.4) | 1.12 (0.95–1.32) | 0.18 | 41.7 (1.8) | 36.0 (1.6) | 1.13 (1.01–1.27) | 0.04 |
| 12 months | 39.0 (2.4) | 38.1 (2.0) | 1.09 (1.00–1.29) | 0.32 | 45.2 (3.3) | 34.7 (2.3) | 1.16 (0.97–1.38) | 0.10 | 42.0 (2.1) | 36.4 (1.6) | 1.12 (0.99–1.27) | 0.06 |
| Pooled | 1.14 (1.00–1.29) | 0.05 | 1.11 (0.98–1.38) | 0.11 | 1.13 (1.03–1.23) | 0.01 | ||||||
25(OH)D data are reported as mean (sem). Change from baseline ratio represents change in total 25(OH)D for D3 group/change in total 25(OH)D for D2 group (95% CI).