Figure 1.

Representation of BER. Subpathways involving single-nucleotide replacement (Left) or a “long-patch” replacement of less than 14 nucleotides (ref. 21; Right) are illustrated. Icons are defined in Table 1, and overlapping icons indicate reported interactions as referenced in text. The upper box depicts several possible termini that may arise from chemically induced or enzyme-catalyzed strand cleavage events. PG, phosphoglycolate; dRP, deoxyribose phosphate moiety.