TABLE 2.
Theoretical (single-hit, multitarget) Fits to Survival Curves of Hematopoietic Progenitor (32D cl 3) Cells Comparing Normoxic and Hypoxic Conditions
|
D0 (Gy) |
n
|
|||
|---|---|---|---|---|
| 20% O2 | 3% O2 | 20% O2 | 3% O2 | |
| 32D cl 3 | 1.18 ± 0.08 | 1.13 ± 0.05 | 3.1 ± 1.1 | 13.9 ± 4.7 |
| 32D cl 3 + 5 mM l-argininea | 1.56 ± 0.02 (*P = 0.040) | 1.20 ± 0.01 | 3.1 ± 0.2 | 18.0 ± 3.3 |
Notes. The uncertainties given are standard errors.
*
When compared with controls, significant differences were observed only when l-arginine was added at 20% O2.
a
Additions made to the culture medium 1 h prior to irradiation.