TABLE 3.
Theoretical (single-hit, multitarget) Fits to Survival Curves of NOS Knockdown Hematopoietic Progenitor (32D cl 3) Cells
| siRNA | D0 (Gy) | n |
|---|---|---|
| Control | 1.25 ± 0.05 | 3.9 ± 2.4 |
| NOS1 | 1.48 ± 0.08 (*P < 0.05) | 1.5 ± 0.5 |
| NOS1 + 5 mM l-argininea | 1.59 ± 0.10 (*P < 0.05) | 1.4 ± 0.3 |
| NOS2 | 1.27 ± 0.17 | 4.6 ± 3.3 |
| NOS3 | 1.23 ± 0.13 | 3.1 ± 2.0 |
Notes. The uncertainties given are standard errors.
When compared with controls, significant differences were observed only with NOS1 knocked down, irrespective of the presence of l-arginine. Fits to survival curves are provided as Supplementary Material (http://dx.doi.org/10.1667/RR1281.1.S1).
Additions made to the culture medium 1 h prior to irradiation.