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Simulation of cooperative binding to a trimeric protein with negative cooperativity. Data were generated in silico based on parameters ET = 1 μM dimer, k1 = 0.01 μM, k2 = 0.1 μM, and k3 = 10 μM with ±2% random error. Line represents least-squares fit of the data. k1 = 0.01 μM; k2 = 0.107 μM; k3 = 9.39 μM.
