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Mechanisms Underlying Oxygen-Induced Hypercapnia
| Loss of hypoxic pulmonary vasoconstriction, stripping perfusion from well-ventilated lung units, leading to increased pulmonary dead space |
| Haldane effect |
| Loss of central drive |
| Gradual increase in actual FIO2 from noninvasive source with falling minute ventilation |
| Sleep onset leading to loss of wakefulness drive to breathe |
