Figure 3.
Quantification in the ipsilateral dorsal horn of formalin-induced Fos expression and evoked NK1-R internalization after carrageenan-induced inflammation. (a–c) Formalin-induced Fos expression. (d,e) NK1-R internalization evoked by noxious mechanical pinch (d) or light brush (e) after carrageenan-induced inflammation. Artemin or vehicle was administered immediately (a,c–e) or 2 d after injury (b). Responses are shown at 14 d (a,b,d,e) or 6 months (c) following injury. * indicates a significantly (P < 0.0001) restored response compared with DRC and vehicle treatment. Error bars, s.e.m.