Systemic artemin administration promotes recovery of sensorimotor function. (a–l) We examined the ability to walk along an elevated beam over an open area (a–c), the number of foot slips when walking across a horizontal ladder (d–f), placement stabilization (g–i) and contact-evoked grasping (j–l) after sham or DRC injury and treatment with six subcutaneous injections of artemin or vehicle. Artemin or vehicle were administered immediately (a,c,d,f,g,i,j,l) or 2 d after injury (b,e,h,k). Responses are shown over a 6-week period following injury (a,d,g,j), or at 14 d (b,e,h,k) or 6 months (c,f,i,l) following injury. * indicates a significantly (P < 0.0001) restored response compared with DRC and vehicle treatment. Error bars, s.e.m.