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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Neural Eng. 2011 Nov 4;8(6):065007. doi: 10.1088/1741-2560/8/6/065007

Table 1.

Summary of each of five proposed biophysical explanations for HFS-induced conduction block, the study authors and the nature of the authors’ explanation.

Explanation Investigator Nature of Explanation
Reacting Chemical Species Cattell and Gerard 1935 [3] Hypothetical surmise (several possibilities considered)
Extracellular Cation Accumulation Cattell and Gerard 1935 [3] Hypothetical surmise (several possibilities considered)
Intracellular Cation Accumulation Bowman 1981 [7] Calculated estimate of Nernst potential changes with accumulation.
Depolarization-induced sodium channel inactivation Kilgore and Bhadra 2004 [1]
Williamson and Andrews 2005 [10]
Bhadra, et. al 2007 [19]
ElBasiouny and Mushahwar 2007 [31]		 Computer simulation of HFS shows membrane depolarization and inactivation of sodium channels are both correlated with conduction block.
Outward potassium current overwhelming inward action potential currents Tai, et. al 2005a [18]
Tai, et. al 2005b [24]
Xu, et. al 2006a [20]
Xu, et. al 2006b [23]
Wang, et. al. 2008 [21]
Hailong, et. al. 2009 [22]		 Computer simulation of HFS shows increased potassium channel activation is correlated with conduction block