. Author manuscript; available in PMC: 2012 Aug 13.

Published in final edited form as: J Lab Autom. 2011 May 16;16(3):197–203. doi: 10.1016/j.jala.2011.02.004

Table 3.

Capabilities of different analytical methods and instrumentation used for quality control of HTS compound libraries.

Analytical Instrument or Method	Precipitate	Empty Wells	Presence of Bubbles	Sample Volume	MW ID	Sample Color	Analysis time, 384-well plate
Nephelometry^10,11,16	yes	no	no	no	no	no	~5-minutes
Acoustic Devices^12–15	^*	yes	^*	yes	no	no	~7-minutes^*
LC-MS⁹	no	no	no	no	yes	yes	3–40 hours^‡
HIAPI-CM	yes	yes	yes	yes	no	yes	~1-minute

Not designed to unambiguously detect problem but will flag acoustic anomalies; the effect of suspended solids/colloids are unknown. Acoustic methods require proprietary consumables.

^‡

Analysis requires destructive sampling