Figure 3.

Dependency of the selectivity entropy on panel size. The Karaman et al. (2008) dataset was divided into 20 random subpanels with 11 different sizes. The selectivity entropies for the promiscuous dasatinib and the selective GW2580 were calculated for each panel. For dasatinib, a reasonable entropy guess can be made from a 200-kinase panel. For GW-2580, which inhibits only two kinases, variation is in practice independent of panel size. For every panel size, SDs were calculated for GW2580 and dasatinib. For a panel size of 200, the SD for dasatinib is 0.10, and the SD for GW2580 is 0.19. If all SDs from all panel sizes are averaged, the final average SD is 0.2.